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versión On-line ISSN 0718-0764
MULLER, Diana M; INGARAMO, María C; ARGARANA, María F y MURGUIA, Marcelo C. Synthesis and Biological Activity of New Peptide-Based Gemini Compounds. Inf. tecnol. [online]. 2011, vol.22, n.5, pp.11-20. ISSN 0718-0764. http://dx.doi.org/10.4067/S0718-07642011000500003.
The antimicrobial activity of new gemini derived from a tetrapeptide has been evaluated. The synthesis was carried out using solid phase chemistry and N - d - direct and indirect alkylation of the ornithine peptide residue . The antimicrobial activity was tested against ATCC strains (American Type Culture Collection) by well-diffusion assay and determination of minimal inhibitory concentration. The method of N- alkylation with potassium carbonate was the best with yields of 40% allows achieving biologically active mono and dialkylate surfactants. The low molecular weight of these compounds, their simple way of preparation and their activity towards bacteria causing food-borne diseases makes them technologycally attractive for use as food preservatives. The presence in the molecules of ornithine gives them enzymatic resistance and a longer biological half-life and thus may be used to develop drugs for therapeutic purposes.
Palabras clave : peptide; gemini; antimicrobial activity; N- d -alkylation; L-Ornithine.