SciELO - Scientific Electronic Library Online

 
vol.20 número4Análisis del Comportamiento Presión-Temperatura en la Transición Isotrópico-Nemático del p-Azoxianisol al variar el alcance del PotencialCinética de la Combustión Sin Llama de Gas Natural sobre CaOMgO índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Información tecnológica

versión On-line ISSN 0718-0764

Resumen

GRIS, Javier H; DRAGONETTI, Martín A; FERNANDEZ, Beatriz M  y  MOGLIONI, Albertina G. Molecular Modelling and Docking Studies of Antiinflammatory Derivatives of 4-Hydroxi, 1,2-Benzothiazine 1,1-Dioxide. Inf. tecnol. [online]. 2009, vol.20, n.4, pp. 51-61. ISSN 0718-0764.  http://dx.doi.org/10.4067/S0718-07642009000400007.

This work points to visualize by computer methods, the way of interaction of oxicanes with ciclooxygenasa, in order to propose a mechanism of action at molecular level, nowadays unknown, and to recognize the functional groups indispensable for analgesic and anti-inflammatory action. The conformacional space was explored and docking of meloxicam, piroxicam, lornoxicam, normeloxicam and 4`meloxicam was performed using the program Flex X. Oxicams present a mode of union to ciclooxigenasa similar to other nonsteroidal anti-inflammatory drugs (NSAID’s), although they show certain significant differences. It is observed that very small structural modifications determine drastic modifications in the selectivity by ciclooxygenasa isoforms.

Palabras clave : cyclooxygenase; oxicams; meloxicam; molecular modelling; docking.

        · resumen en Español     · texto en Español