Resumen

GRIS, Javier H; DRAGONETTI, Martín A; FERNANDEZ, Beatriz M  y  SICARDI, Susana M. Evaluation of the Mutagenic Potential of Piroxicam, Meloxicam and their Precursors using in vivo Micronucleus Test. Inf. tecnol. [online]. 2008, vol.19, n.6, pp. 83-88. ISSN 0718-0764.  doi: 10.4067/S0718-07642008000600009.

Mutagenic potential of piroxicam (1), 2-aminopyridine (2), meloxicam (3) and 2-amino-5-methyl-thiazole (4) has been evaluated using in vivo micronucleus test. Four dose levels for each compound were used and bone marrow cells were examined 24 hours after the administration. In the case of the degradation product of piroxicam (2) only 0.1, 0.3, 1.0 and 5.0 mg/kg were evaluated, because at 50 mg/kg all animals died. The results show that doses applied do not induce a statistical significant increase of the frequency of micronucleated polychromatic erythrocytes. Aniline (5) has been used as positive mutagen reference, showing a positive response to the micronucleous induction at doses of 50mg/kg or superior while no induction occur with lower doses. The structural-mutagenic activity relationship between piroxicam and aniline could not been established.

Palabras clave : piroxicam; meloxicam; mutagenic potential; 2-aminopyridine; aniline.