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vol.57 número2A THEORETICAL STUDY ON THE MECHANISM OF THE ADDITION REACTION BETWEEN CYCLOPROPENYLIDENE AND ETHYLENETOTAL AND MAIN As SPECIES PRESENT IN CARDIOVASCULAR TISSUES OF PEOPLE LIVINGIN As CONTAMINATED AREAS índice de autoresíndice de materiabúsqueda de artículos
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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

PATIL, VIJAYK; REDASANI, VIVEKKUMAR K; VISPUTE, KULDIP R  y  SURANA, SANJAY J. DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.2, pp. 1178-1180. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072012000200026.

A simple, rapid, selective and sensitive RP-HPLC method was developed and validated for the estimation of triflusal. The method was carried out using 5-j1m particle size, C18-bonded silica column, quaternary pump and acetonitrile: 1 mM potassium dihydrogen phosphate (65:35 v/v) pH 3 as the mobile phase with UV detection at 226 nm. The proposed method is advantageous as it follows isocratic elution in short run time (10 min). The result obtained shown that the method best fits for estimation of drug in capsule formulation and thus can be used for its routine analysis. The newly developed method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.

Palabras clave : Triflusal; RP-HPLC; Validation; Specificity; System suitability.

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