Journal of the Chilean Chemical Society
versión On-line ISSN 0717-9707
CANETE, A et al. BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.2, pp.1126-1129. ISSN 0717-9707. http://dx.doi.org/10.4067/S0717-97072012000200015.
We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.
Palabras clave : Quinone; Electrochemical properties; Antiproliferative activity.