Journal of the Chilean Chemical Society
versión ISSN 0717-9707
WARDAKHAN, WAGNAT WAHBA y SAMIR, EMAN MOHAMED. NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.2, pp. 1118-1121. ISSN 0717-9707. doi: 10.4067/S0717-97072012000200013.
The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.
Palabras clave : hydrazide-hydrazone; pyridazine; 1,2,3-triazole; pyrazole; anti-tumor.