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Journal of the Chilean Chemical Society

On-line version ISSN 0717-9707

Abstract

SAMADHIYA, PUSHKAL; SHARMA, RITU; SRIVASTAV, SANTOSH K  and  SRIVASTAVA, SAVITRI D. SYNTHESIS OF 4-THIAZOLIDINE DERIVATIVES OF 6-NITROINDAZOLE: PHARMACEUTICAL IMPORTANCE. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.1, pp. 1036-1043. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072012000100018.

New series of N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine-carboxamide, compounds 5(a-j) have been synthesized from 6-nitroindazole. Structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR, 13C NMR and FAB-Mass. All the synthesized compounds were screened for their antibacterial, antifungal, antitubercular and antiinflammatory activities.

Keywords : 6-nitroindazole; thiazolidinone; antimicrobial; antitubercular; antiinflammatory.

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