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Journal of the Chilean Chemical Society

On-line version ISSN 0717-9707

Abstract

PATIL, AMOD S; SHIRKHEDKAR, ATUL A; SURANA, SANJAY J  and  NAWALE, PRAJAKTA S. SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY. J. Chil. Chem. Soc. [online]. 2012, vol.57, n.1, pp. 1033-1035. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072012000100017.

A simple, rapid and sensitive RP- HPTLC method has been established for the determination of Propranolol hydrochloride (PRH) and Flunarizine Dihydrochloride (FNZ) in bulk and capsule formulation. Separation of both these drugs were achieved on aluminum backed silica gel 60 RP-18 F254S HPTLC plates, prewashed with methanol using methanol: toluene: ammonia (7:3:0.5 v/v) as mobile phase. Densitometric scanning was performed at 267 nm. The Rf values for PRH and FNZ were found to be 0.63 and 0.48, respectively. The amount of PRH and FNZ estimated in capsule formulation were found to be 99.20 ± 1.04 and 98.89 ± 1.23, respectively. The accuracy of the method was found to be in the range of 99.30 - 100.41% for PRH and 99.56 -100.87 for FNZ. The method was validated as per ICH guidelines and can regularly used for analysis of PRH and FNZ in capsule dosage form.

Keywords : Propranolol hydrochloride; Flunarizine dihydrochloride; RP- HPTLC.

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