Journal of the Chilean Chemical Society
versión On-line ISSN 0717-9707
MOBINIKHALEDI, A; JABBARPOUR, M y HAMTA, A. SYNTHESIS OF SOME NOVEL AND BIOLOGICALLY ACTIVE SCHIFF BASES BEARING A 1,3,4-THIADIAZOLE MOIETY UNDER ACIDIC AND PTC CONDITIONS. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.3, pp.812-814. ISSN 0717-9707. http://dx.doi.org/10.4067/S0717-97072011000300020.
The synthesis of some new Schiff bases bearing a 1,3,4-thiadiazole moiety, 3a-l, by reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with aromatic aldehydes under acidic and phase transfer catalyst (PTC) conditions was studied. The structure of all the Schiff bases was characterized using FT-IR and NMR spectroscopy, and elemental analyses. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia coli (ATCC, 35922).
Palabras clave : Schiff base; 1,3,4-thiadiazole; biological activities; PTC.