SciELO - Scientific Electronic Library Online

 
vol.56 número3PHOTOELECTROCHEMICAL REDUCTION OF NITRATE IONS ON POROUS SILICON AND DIFFERENT SILICON MODIFIED ELECTRODESLIQUID-PHASE HYDROGENATION OF m-DINITROBENZENE OVER PLATINUM CATALYSTS índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

ATRIA, ANA MARÍA et al. X-RAY STUDIES AND ANTIBACTERIAL ACTIVITY IN COPPER AND COBALT COMPLEXES WITH IMIDAZOLE DERIVATIVE LIGANDS. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.3, pp. 786-792. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000300015.

The complexes Diaqua-bis(5-nitroimidazole)-copper(II)-dinitrate (1); Tetrakis(4- phenylimidazole)-copper(II)-dinitrate, ethanol solvate (2); Bis(4-phenylimidazole)-bis(acetate)-copper(II) (3); Hexakis(4-phenylimidazole)-cobalt(II)-acetate (4) and Bis(2- phenylimidazole)-bis(acetate)-cobalt(II) (5), have been synthesized. Their structures were determined by X-ray analysis. The antimicrobial activities of these complexes have been screened in vitro against the microorganisms Escherichia coli, Klebsiella pneumoniae, Shigella flexneri, Salmonella typhi, Salmonella enteritidis, Salmonella entérica, Staphylococcus aureus, Listeria monocytogenes. Complexes (1) and (3) showed antimicrobial activity over Gram positive and negative bacteria by a bacteriostatic effect. On the other hand, complexes (4) and (5) showed antibacterial activity with a bacteriolytic effect over Gram positive and negative bacteria. The cytotoxicity of complexes (3) and (4) was tested in vitro. These complexes presented cytotoxic effect to values near the MIC.

Palabras clave : copper; cobalt crystal structure; antibacterial activities.

        · texto en Inglés     · pdf en Inglés