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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

HUSAIN, ASIF; AHMAD, AFTAB; BHANDARI, ANIL  y  RAM, VEERMA. SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.3, pp. 778-780. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072011000300013.

Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.

Palabras clave : Pyridazinone; antitubercular; mycobacteria; furanone.

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