Journal of the Chilean Chemical Society
versión ISSN 0717-9707
ROGEL, CRISTIAN et al. FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES. J. Chil. Chem. Soc. [online]. 2011, vol.56, n.1, pp. 574-578. ISSN 0717-9707. doi: 10.4067/S0717-97072011000100011.
The interaction between Florfenicol (FF), Hydroxypropyl-β-cyclodextrin (HPβCD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HPβCD and only Spray Drying for Chitosan. The phase solubility study shows that the complex is formed with 1:1 stoichiometry and 181,4 M1 as the association constant. The analysis with Differential Scanning Calorimetry (DSC) together with Scanning Electron Microscopy (SEM) micrographs evidenced the formation of inclusion complexes, mainly with the product prepared by spray drying. Studies in vitro showed that FF solubility was improved almost to double, with a better dissolution profile exhibited by the product prepared by spray drying.