Journal of the Chilean Chemical Society
versión On-line ISSN 0717-9707
KUMAR, KIRAN; KAITH, B. S y MITTAL, HEMANT. UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID. J. Chil. Chem. Soc. [online]. 2010, vol.55, n.4, pp. 522-526. ISSN 0717-9707. http://dx.doi.org/10.4067/S0717-97072010000400025.
In this paper, psyllium (Psy) and acrylamide (AAm) based superabsorbent, synthesized using potassium persulphate (KPS) as an initiator and hexamethylene tetramine (HTMA) as a crosslinker, has been investigated for its swelling behaviour in distilled water as a function of time, temperature and pH. The hydrogel has further been applied for controlled delivery of 5-amino salicylic acid (5-ASA) under different pH conditions at 37 oc. It has been found to show Fickian type mechanism as the drug release showed diffusion coefficient less than 0.50 for all the pH conditions.The gel characteristic constant has been found to show 6.9 x 102, 20.61 X 102 and 33.4 x 102 values for pH 4.0, 7.0 and 9.2, respectively. The initial diffusion coefficient has been found to show greater values than late diffusion coefficient confirming greater release at the early stages of the drug release than that in the late stages.
Palabras llave : psyllium; acrylamide; 5-amino salicylic acid; drug delivery; superabsorbent.