Resumen

JAYACHANDRA REDDY, B  y  SOMASEKHARA REDDY, M.C. SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES. J. Chil. Chem. Soc. [online]. 2010, vol.55, n.4, pp. 483-485. ISSN 0717-9707.  doi: 10.4067/S0717-97072010000400016.

The quinoxaline derivatives (i-v) were synthesized through cyclization-oxidation of a- bromo carbonyl compounds with o-phenyl diamines (7a and 10a) and further coupling at 6-position via Suzuki reaction using PdCl₂ (dppf).DCM, ter. BuNH₂, Na₂CO₃ in IPA, H₂O refluxed for 16 h. As the results of antibacterial screening tests done by paper disc method, quinoxaline derivatives (i) and (v) revealed significant inhibition zone on Bacillus spericus and quinoxaline derivatives (iii) and (v) on Escherichia coli cultures.

Palabras clave : Quinoxaline; Suzuki; Coupling; microwave; Bacillus spericus; Escherichia coli.