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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

JAYACHANDRA REDDY, B  y  SOMASEKHARA REDDY, M.C. SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES. J. Chil. Chem. Soc. [online]. 2010, vol.55, n.4, pp. 483-485. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072010000400016.

The quinoxaline derivatives (i-v) were synthesized through cyclization-oxidation of a- bromo carbonyl compounds with o-phenyl diamines (7a and 10a) and further coupling at 6-position via Suzuki reaction using PdCl2 (dppf).DCM, ter. BuNH2, Na2CO3 in IPA, H2O refluxed for 16 h. As the results of antibacterial screening tests done by paper disc method, quinoxaline derivatives (i) and (v) revealed significant inhibition zone on Bacillus spericus and quinoxaline derivatives (iii) and (v) on Escherichia coli cultures.

Palabras llave : Quinoxaline; Suzuki; Coupling; microwave; Bacillus spericus; Escherichia coli.

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