Resumen

SINGH, HEMENDRA PRATAP; CHAUHAN, C S; PANDEYA, S N  y  SHARMA, CHANDRA SHEKHAR. CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY. J. Chil. Chem. Soc. [online]. 2010, vol.55, n.1, pp. 103-106. ISSN 0717-9707.  doi: 10.4067/S0717-97072010000100024.

During our investigation in the area of epileptic drug discovery, we have identified that the available conventional antiepileptic drugs are effective in 60-80% patients and in specific type of seizures and having various undesirable side effects. But in present time aonew class aryl semicarbazone is emerged asonew pharmacophore in epileptic drug discovery having broad spectrum activity. On the bases of work done in this area we have applied hybridization of pharmacophore strategy of drug design and developed aonew pharmacophore. We have also designed a scheme for synthesizing such pharmacophore and performed their pharmacological screening for the protection of seizures, behavioral study and CNS activity. The compound 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl) allylidene]-4-(2-fluorophenyl) semicarbazide (8) emerged as the most active prototype molecule in all the models.

Palabras clave : semicarbazide; actophotometer; antiepileptic.