Resumen

PATIL, U. P; GANDHI, S. V; SENGAR, M. R  y  RAJMANE, V. S. A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION. J. Chil. Chem. Soc. [online]. 2010, vol.55, n.1, pp. 94-96. ISSN 0717-9707.  doi: 10.4067/S0717-97072010000100022.

A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F₂₅₄ as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.

Palabras clave : High-performance thin-layer chromatography; telmisartan; atorvastatin calcium.