Journal of the Chilean Chemical Society
versión On-line ISSN 0717-9707
CASTRO-CASTILLO, VICENTE; REBOLLEDO-FUENTES, MARCO y CASSELS, BRUCE K. SYNTHESIS OF A-RING-SUBSTITUTED 5,6,8,12B-TETRAHYDROISOINDOLO[1,2-A]ISOQUINOLIN-8-ONES. J. Chil. Chem. Soc. [online]. 2009, vol.54, n.4, pp. 417-423. ISSN 0717-9707. doi: 10.4067/S0717-97072009000400021.
The synthesis of 4,5,8,12b-tetrahydroisoindolo[1,2-a]isoquinolin-8-ones is reviewed The unsubstituted parent compound, a series of fourteen A-ring-substituted derivatives, most of them new, and some of their doubly benzylic, 12b-hydroxylated oxidation products were synthesized. Unusual features of their reactivity are briefy discussed.