SciELO - Scientific Electronic Library Online

 
vol.54 número4PREPARATION OF MANGANESE DIOXIDE MODIFIED GLASSY CARBON ELECTRODE BY A NOVEL FILM PLATING/CYCLIC VOLTAMMETRY METHOD FOR H(2)0(2) DETECTIONADSORPTION OF MULTIWALLED CARBON NANOTUBES ON ELECTROSPUN POLYCAPROLACTON NANOFIBERS índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

SHAMSUZZAMAN; SHAHEEN KHAN, MOHD  y  ALAM, MAHBOOB. SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING. J. Chil. Chem. Soc. [online]. 2009, vol.54, n.4, pp. 372-374. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072009000400010.

The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6), respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria.

Palabras llave : thiosemicarbazide; pyrazolines; cholest-5-en-7-one; thiocarbamoyl; anti-bacterial activity.

        · texto en Inglés     · pdf en Inglés