Abstract

PESSOA-MAHANA, HERNÁN et al. SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT_1A BINDING AFFINITY. J. Chil. Chem. Soc. [online]. 2009, vol.54, n.2, pp. 147-150. ISSN 0717-9707.  doi: 10.4067/S0717-97072009000200011.

New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT_1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.

Keywords : Secotonine; arylpiperazines; 5-HT_1A binding affiniy.