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Journal of the Chilean Chemical Society

versión On-line ISSN 0717-9707

Resumen

LIU, HE et al. SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE. J. Chil. Chem. Soc. [online]. 2006, vol.51, n.3, pp. 961-963. ISSN 0717-9707.  http://dx.doi.org/10.4067/S0717-97072006000300006.

Thiencynonate hydrochloride (N-methyL-9á-(3-azabicyclo[3,3,1]nonanyl)-2'-cyclopentyL-2'- hydroxyL-2'-thienylacetate, HCl), an new muscarinic receptor antagonist, was synthesized and its enantiomers were obtained form the optical pure of demethylation product II. A convenient resolution method of demethylation product II has been developed with N-p- toluenesulfonylglutamic acid as the resolution reagent. The structures of I and II were elucidated by X-ray analysis

Palabras llave : Thiencynonate hydrochloride; optical resolution; anticholinergic Drug.

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