Journal of the Chilean Chemical Society
versión On-line ISSN 0717-9707
LIU, HE et al. SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE. J. Chil. Chem. Soc. [online]. 2006, vol.51, n.3, pp. 961-963. ISSN 0717-9707. doi: 10.4067/S0717-97072006000300006.
Thiencynonate hydrochloride (N-methyL-9á-(3-azabicyclo[3,3,1]nonanyl)-2'-cyclopentyL-2'- hydroxyL-2'-thienylacetate, I·HCl), an new muscarinic receptor antagonist, was synthesized and its enantiomers were obtained form the optical pure of demethylation product II. A convenient resolution method of demethylation product II has been developed with N-p- toluenesulfonylglutamic acid as the resolution reagent. The structures of I and II were elucidated by X-ray analysis
Palabras clave : Thiencynonate hydrochloride; optical resolution; anticholinergic Drug.