SciELO - Scientific Electronic Library Online

 
vol.30 número2Efecto de un Programa de Ejercicios Grupales sobre la Función Muscular entre Mujeres de Edad Avanzada Propensas a CaídasPerforación de la Vena Axilar por una Rama de la Arteria Axilar: un Estudio Anatómico índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

International Journal of Morphology

versión On-line ISSN 0717-9502

Resumen

GARCIA-JUAREZ, Jaime et al. Evaluation of the Effect of Treatment with Lipoic Acid Administered to the Wistar Rat Intoxicated with the Fruit of Karwinskia humboldtiana. Int. J. Morphol. [online]. 2012, vol.30, n.2, pp. 572-578. ISSN 0717-9502.  http://dx.doi.org/10.4067/S0717-95022012000200035.

The accidental ingestion of Karwinskia humboldtiana causes a flaccid, symmetrical, progressive and ascending paralysis, similar to Guillain-Barre syndrome. It evolves over the course of 3 to 12 months until full recovery, but severe cases end in death due to respiratory failure. There is no specific treatment. The histopathological lesions described in peripheral nerve of patients and in experimental animals, corresponds to segmental demyelination accompanied by Wallerian degeneration. One of the toxins extracted from the seed, T-514, causes an increase of free radicals in vitro. Free radicals have been associated to demyelination that occurs in other types of neuropathy such as diabetic neuropathy. Since the ultrastructural damage that occurs in animal models of diabetes is similar to that observed in experimental poisoning with the fruit of K. humboldtiana, we decided to administer a powerful antioxidant, a-lipoic acid, in a model of chronic poisoning due of K. humboldtiana. However, no improvement was observed on the clinical manifestations evaluated in animals or in the histopathological lesions in the peripheral nerve. These results suggest that free radicals are not the primary mechanism of injury on the peripheral nerve caused by K. humboldtiana.

Palabras llave : Karwinskia humboldtiana; Lipoic acid; Polyneuropathy; Demyelination; Paralysis.

        · resumen en Español     · texto en Español     · pdf en Español