International Journal of Morphology
versión On-line ISSN 0717-9502
BERNARDES, Vanessa Fátima et al. Intraoral Mucoepidermoid Carcinoma of Salivary Glands: Lack of Association Among Clinicopathological Features and Immunoexpression of c-erbB-2 in 29 Cases. Int. J. Morphol. [online]. 2008, vol.26, n.4, pp. 1005-1011. ISSN 0717-9502. doi: 10.4067/S0717-95022008000400036.
The association among clinicopathological features and c-erbB-2 oncoprotein expression was evaluated in twenty-nine cases of intra-oral mucoepidermoid carcinoma (MEC). MEC was prevalent in the female gender (79.3%), tumors were more frequent in ages between 21 and 40 years (48.3%), and the palate was the most commonly affected site (72.4%). Microscopically, 27 cases (93.1%) were classified as low grade of malignancy. The c-erbB-2 expression was considered positive in 9 (31%) cases and no significant association (p>0.05) was found among protein expression and gender ñor between patient age and site or histological grade of the lesión. c-erbB-2 expression in MEC may reflect intrisinc biologic properties of salivary gland neoplasms and may be linked to histogenesis and cellular differentiaton.
Palabras clave : c-erbB-2; Her-2/neu; Immunohistochemistry; Mucoepidermoid carcinoma; Salivary gland neoplasms.