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International Journal of Morphology
versión On-line ISSN 0717-9502
CATROXO, M. H. B et al. Torque Teno Virus (TTV) is Prevalent in Brazilian Non-human Primates and Chickens (Gallus gallus domesticus). Int. J. Morphol. [online]. 2008, vol.26, n.2, pp.363-372. ISSN 0717-9502. http://dx.doi.org/10.4067/S0717-95022008000200018.
Torque Teno virus (TTV) is an infectious agent of worldwide distribution isolated by the first time as the agent of an acute post-transfusion hepatitis in a patient in Japan. It has been classified into a new floating genus called Anellovirus. Recent studies showed that TTV can also be identified in serum specimens obtained from domesticated farm animals and from non-human primates. To better understand the relationship between TTV and their hosts, a study to detect virus in the serum and whole blood of Brazilian non-human primates and in the plasm of chickens was performed by applying the PCR-UTR-A technique, followed by a genomic sequence and phylogenetic analysis. By nested-PCR-UTR, the DNA of TTV was detected in sera from 4 (5.3%) of 75 Cebus apella, 2 (40%) of 5 Alouatafusca, 1 (20%) of 5 Alouata caraya, 1 (5.2%) of 19 Callithrixpenicilata, 1 (4%) of 25 Callithrixjacchus, 1 (20%) of 5 Saimiri sciureus and 1 (25%) of 4 Leontopithecus chrysomelas. Phylogenetic analysis revealed that sequences detected in 8 samples clustered with TTV sequences So-TTV2 (Sagüínus oedipus) and At-TTV3 (Aotes Trivirgatus). Three sequences showed similarity with a human Torque Teno Minivirus (TLMV). TTV ORF2 DNA was detected in one sera sample and one whole blood sample of non-human primates and in one plasm sample of chicken. Phylogenetic analysis revealed that the sequences amplified by the ORF2 region show no difference between human, non-human primates and chicken. This is the first report of TTV in brazilian new world non-human primates and chicken.
Palabras clave : Torque Teno Virus; Torque Teno Minivirus; Non-humans primates; Untranslated region; Nucleotide sequencing.