Revista chilena de radiología
versión On-line ISSN 0717-9308
ROJAS C, Raúl et al. COMPROMISO OSEO EN HISTIOCITOSIS DE CELULAS DE LANGERHANS EN EL NIÑO: ESTUDIO RADIOLOGICO SIMPLE. PRESENTACION CLINICA Y DIAGNOSTICO RADIOLOGICO. Rev. chil. radiol. [online]. 2005, vol.11, n.3, pp.116-121. ISSN 0717-9308. http://dx.doi.org/10.4067/S0717-93082005000300005.
Introduction. Langerhans' cell histiocytosis is an uncommon disease, with various radiological presentations. Its cause remains unknown, with the pathological hallmark being proliferation of Langerhans' cells. The spectrum of disease ranges from solitary bone lesions to multisystemic affection. Usually, the first diagnostic test performed is the plain radiograph, and the radiological findings may be hard to analyze. Differential diagnosis should include osteomyelitis, Ewing's sarcoma and lymphoma. Objectives: To show the plain radiographic findings of LCH, that allow the radiologist to suspect it. Methods and materials: The clinical and radiological presentations of the biopsy proven LCH cases of the National Bone Tumor File (RENATO) between the years 1961 and 1999 were analyzed retrospectively. Results: From a total of 59 patients, 58% were boys and 42% were girls. Age ranged from 0.8 to 17 years, with an average of 6.1 years. Medical history was obtained in 56 cases (95%). The mean duration of symptoms at diagnosis was 5,5 months, with pain at the site of affection being the most frequent 50/59 of them. Forty-eigth patients (81%) presented with a solitary bone lesion and 11 (19%) presented with two or more lesions; 35 patients had afection of long bones and 26 of axial skeleton. The most frequently radiological pattern was a purely osteolytic lesion (n=45). 13 patients presented with a permeative lesion and a vertebra plana was found in 3. Periostal reaction and soft tissue mass were found in 30 and 29 cases respectively. Conclusions: Despite the fact that LCH has several radiological manifestations, its diagnosis should be suspected by the radiologist. This study with biopsy proven cases of Langerhans´ cell histiocytosis allows us to characterize the manifestations of this disease in the skeleton and is useful for the differential diagnosis of a bone lesion in the pediatric patient
Palabras clave : Eosinophilic granuloma; Histiocytosis X; Langerhans' cell histiocytosis.