Revista chilena de radiología
versión On-line ISSN 0717-9308
OYANEDEL Q, Roberto et al. TUMOR ESTROMAL GASTROINTESTINAL (GIST): FORMAS DE PRESENTACION . Rev. chil. radiol. [online]. 2005, vol.11, n.1, pp. 13-18. ISSN 0717-9308. http://dx.doi.org/10.4067/S0717-93082005000100005.
Gastrointestinal Stromal Tumors (GIST) are rare tumors, accounting for less than 3% of gastrointestinal neoplasms, however, they are the most frequent mesenchymal tumors of the GI tract. All GISTs are defined by the expression of CD117, a tyrosine kinase growth factor receptor, as opposed to other tumors like leiomyomas, leiomyosarcomas and neurogenic tumors. 70-80% are benign, and the majority is located in the stomach and small bowel, but also they can arise from any portion of the GI tract as well as from the mesentery, omentum and retroperitoneum. Malignant GISTs are usually large (>5 cm), with high mitotic index, and can metastasize to the liver and peritoneum. CT findings that suggest GIST are: exofitic mass arising from bowel wall, well-circumscribed, that can present hemorrhage, necrosis and/or cystic component, and rarely is associated with bowel obstruction. Treatment is surgical resection. Therapy with tyrosine kinase inhibitor STI571 is promising
Palabras llave : Gastrointestinal tumor; Stromal tumor.