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Revista chilena de neuro-psiquiatría

versão On-line ISSN 0717-9227

Resumo

SILVA, Hernán. Mechanisms of Action of Mood Stabilizers. Rev. chil. neuro-psiquiatr. [online]. 2001, vol.39, n.3, pp.219-230. ISSN 0717-9227.  http://dx.doi.org/10.4067/S0717-92272001000300006.

Objective: To analyze the progress made in the understanding of the mechanisms of action of mood stabilizers and their clinical relevance. Method: A critical review of the literature with an emphasis on reviews and clinical reports. Results: Initial mechanisms of action of mood stabilizers are heterogeneous, but their common long-term actions are the most important. Lithium and valproate inhibit the glycogen synthase kinase 3 beta and reduce the protein kinase C. The lithium reduction of protein kinase C is mediated by the depletion of inositol. Lithium and valproate also affect G proteins, but these effects are not completely understood. These actions induce changes in transcriptional factors, the expression of early genes and the production of neurotrophic factors in the central nervous system. The result is a series of plastic changes in specific neuronal populations. Conclusions: Knowledge of the mechanisms of action of mood stabilizers, mainly their cellular, genetic and molecular effects, has increased. This knowledge can stimulate the development of new drugs for treating mood disorders

Palavras-chave : mood stabilizers; lithium; valproate; neural plasticity.

        · resumo em Espanhol     · texto em Espanhol

 

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