Revista chilena de obstetricia y ginecología
versión On-line ISSN 0717-7526
SERMAN V, Felipe et al. Concordancia entre histología pre, intra y postoperatoria en cáncer de endometrio. Rev. chil. obstet. ginecol. [online]. 2012, vol.77, n.4, pp. 280-285. ISSN 0717-7526. http://dx.doi.org/10.4067/S0717-75262012000400007.
Background: Among patients with endometrial cancer there is discussion about concordance between pre and intraoperatory biopsy and the definitive one, for diferentiation grade, histologyc type and depth of myoinvasion. Method: To determinate sensibility (S), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of: good diferenciated diferentiation grade and only endometrioid histologyc type on preoperatory biopsy, and good diferenciated diferentiation grade, only endometrioid histologyc type and inner half of the miometryum or less myoinvasion depth on intraoperatory biopsy, for similar result on definitive biopsy in a clinical cohort of patients with endometrial cancer clinically limited to uterus treated with primary surgery. Results: Preoperatory biopsy: good diferentiated diferentiation grade S: 100%, Sp: 77.8%, PPV: 78.9% and NPV: 100%. Only endometrioid histologyc type S: 86.4%, Sp: 33.3%, PPV 86.4% and NPV 33.3%, for similar result on definitive biopsy. Intraoperatory biopsy: Good diferentiated diferentiation grade S: 91.7%, Sp: 94.4%, PPV: 91.7% and NPV 100%. Only endometrioid histologyc type S: 95.7%, Sp 77.8%, PPV 95.7% and NPV 70%. Inner half of the myometrium or less myoinvasion depth S: 95.2%, Sp 30%, PPV 74.1% and NPV 75%, for similar result on definitive biopsy. Conclusion: There wasn't absolute concordance of good diferentiated diferentiation grade between preoperatory and definitive biopsy. Also there weren't absolute concordance of neither good diferentiated diferentiation grade, nor only endometrioid histologyc type, between intraoperatory and definitive biopsy, for that it is recommended surgical staging, independent of results of pre and intraoperatory biopsies.
Palabras clave : Endometrial cancer; biopsy accuracy; surgical staging.