Revista chilena de obstetricia y ginecología
On-line version ISSN 0717-7526
ALONSO M, Catalina; BRAVO O, Erasmo; ROJAS S, Sergio and PARRY R, Santiago. Histerectomía extrafascial en cáncer de cuello uterino IB2 posterior a radio-quimioterapia. Rev. chil. obstet. ginecol. [online]. 2012, vol.77, n.2, pp.93-97. ISSN 0717-7526. http://dx.doi.org/10.4067/S0717-75262012000200003.
Aim: To evaluate overall and disease free survival in cervical cáncer IB2 patients with concomitant chemo-radiotherapy and posterior extrafascial hysterectomy treatment. Methods: Between July 2005 to December 2009, a total of 31 eligible patients with IB2 cervical cancer were treated with chemoradiotherapy and posterior hysterectomy in the Carlos Van Buren Hospital Oncology Unit. Radiotherapy consisted in external pelvic radiation and a utero-vaginal brachitherapy with low rate doses to get preoperatory doses between 70 and 75 Gy to the A point and a concomitant Cisplatin based chemotherapy. After this treatment, the patients received extrafascial hysterectomy 4 to 6 weeks completed chemoradiotherapy. Results: The mean age was 41 ± 8 years. 81% of the patients had an spinocelular carcinoma. The extrafascial hysterectomy was made between 4 to 6 weeks post-radiation in 85% of the patients. 79% and 13% of the patients received 5 and 4 chemotherapy cycles respectively. The median follow up was 38 months. The 5 years overall survival and disease free survival estimates were 86% and 79% respectively. There was a significant difference between subgroups of patients with and without macroscopic residual disease in the operatory specimen (p<0.001). Conclusion: Our survival is similar to published results with the same treatment. The presence of macroscopic residual disease in the hysterectomy specimen could be a factor of prognostic value.
Keywords : Cervical carcinoma IB2; chemoradiotherapy; extrafascial hysterectomy.