Revista chilena de obstetricia y ginecología
versión On-line ISSN 0717-7526
PARRA C, Mauro et al. ESPECTRO CLÍNICO DE LA PREECLAMPSIA: ESTUDIO COMPARATIVO DE SUS DIVERSOS GRADOS DE SEVERIDAD. Rev. chil. obstet. ginecol. [online]. 2007, vol.72, n.3, pp. 169-175. ISSN 0717-7526. doi: 10.4067/S0717-75262007000300007.
Objective: The aim of this study was to compare maternal and perinatal outcome in pregnant women with the different spectrum of severity of pre-eclampsia (PE). Methods: A retrospective study in 7205 pregnancies delivered at the University of Chile Hospital. 204 pregnant women were diagnosed preeclampsia, which were divided in three groups: moderate PE, severe PE, and HELLP syndrome, according to standard definitions. The maternal and perinatal outcomes were analyzed between groups and statistically differences were considered when p<0.05. Analyses of variance (ANOVA) and Chi2 or Fisher's exact tests were used for continuous or categorical variables, respectively. Results: 80 women were moderate PE (39.2%), 114 severe PE (55.8%), and 10 HELLP (4.9%). Rate of cesarean section, birthweight, gestational age, fetal percentile, neonatal mortality and morbidity and medical and surgical maternal morbidity were significantly different between severe conditions and moderate one. 24-hours proteinuria was significantly higher in severe PE compared to other groups. Furthermore, levels of liver enzymes and lactate deshydrogenase were higher and platelet count lower in HELLP syndrome compared to moderate and severe cases. Conclusion: This study confirms that there are different clinical and biochemical manifestations according to the grade of severity of the preeclampsia, being worst in those with severe conditions and HELLP syndrome compared to moderate cases. Therefore, a correct classification, according to strict clinical criteria and laboratory parameters, would be essential for appropriate treatment and prognosis
Palabras clave : Preeclampsia; HELLP syndrome; maternal and neonatal outcome.