Revista chilena de nutrición
versión On-line ISSN 0717-7518
MURRAY M, Nigel P y LEIGHTON G, Gonzalo. RELATION BETWEEN BODY MASS INDEX (BMI) AND DETECTION OF CIRCULATING PROSTATIC CELLS (CPC) IN HEALTHY MEN: A PILOT STUDY. Rev. chil. nutr. [online]. 2007, vol.34, n.4, pp. 346-351. ISSN 0717-7518. http://dx.doi.org/10.4067/S0717-75182007000400008.
Objective. The association between obesity and prostate cancer is controversial, with different giving conflicting results. The objective of this study was to determine the presence of CPC in healthy men and its relationship with BMI (Body Mass Index). Method: 110 healthy men and 10 women took part in the study with an average age of 64.2 years (range 42 to 88 years) and an average PSA of 3.92 ng/mL (range 0.02-40 ng/mL). The mononuclear cells were separated using differential centrifugation and identified using monoclonal antibodies against PSA and CD45. PSA-positive cells and CD45-negative cells were classified as prostatic. Results: 0% of the women and 28% of men had CPC detected. Positive men had an average BMI higher than negative men (P<0,005), and there was a correlation between the frequency of positive cases and BMI (p<0,0005). In men with a PSA of less than 10ng/ml there was no correlation with the BMI. Conclusions: The incidence of CPC increases with BMI, supporting the hypothesis that prostate cancer is associated with obesity. If the results are confirmed in a larger population, the detection of CPC would be a powerful tool in early identification of patients with prostate cancer, especially in overweight or obese men where the PSA has been questioned
Palabras clave : prostate cancer; obesity; overweight; circulating tumour cells.