Revista chilena de nutrición
versión On-line ISSN 0717-7518
AGUDELO O, Gloria Maria et al. SERUM CONCENTRATIONS OF FREE COPPER AND CERULOPLASMIN IN CHILDREN WITH SEVERE ACUTE MALNUTRITION BEFORE NUTRITIONAL THERAPY AND AFTER CHILDREN HAVE RECOVERED THE APETITE IN TURBO, ANTIOQUIA, COLOMBIA. Rev. chil. nutr. [online]. 2006, vol.33, n.2, pp. 188-197. ISSN 0717-7518. doi: 10.4067/S0717-75182006000200008.
Introduction: copper supplementation therapy has been used in children with acute and severe malnutrition. Scientific evidence has shown that malnourished children with edema have free copper in plasma which could produce oxidative stress. Objective: To compared plasma concentrations of free copper between children with acute and severe malnutrition and a control group. Methodology: Cross sectional study where 66 normal and malnourished children were studied. A longitudinal study (before and after type) design was used including 40 children with severe and acute malnutrition; free copper was merasured by high-resolution capillary electrophoresis; ceruloplasmin and PCR by nephelometry. Results: In the cross sectional study children with marasmus had higher free copper serum concentrations than children with oedematous malnutrition, but the difference was not significant. In the control group this metal was not found. Children with oedema showed significant lower ceruloplasmin concentrations than children with marasmus (p=0.00) while the difference in PCR was also no significant for both groups. When the relationship between free copper serum concentrations and the presence of infection was analyzed no significant differences were obtained. However, serum albumin concentration was significantly lower for children with oedematous malnutrition than the marasmic group (p=0.016). After children recovered the appetite in the longitudinal study, serum free copper concentration decreased for both groups and ceruloplasmin concentration increased but no significant differences were observed. Conclusion: Copper supplementation could be considered as nutritional therapy for undernourished children since the beginning of the nutritional treatment, as it is recommended by WHO
Palabras clave : marasmus; oedematous malnutrition; oedema; copper-free ceruloplasmin.