Revista chilena de nutrición
versión On-line ISSN 0717-7518
SANHUEZA C, Julio y VALENZUELA B, Alfonso. NUCLEAR RECEPTORS AND REGULATION OF GENE EXPRESSION BY POLYUNSATURATED FATTY ACIDS: SOMETHING MORE THAN ENERGY PRODUCTION AND ESSENTIALITY. Rev. chil. nutr. [online]. 2006, vol.33, n.2, pp. 150-161. ISSN 0717-7518. doi: 10.4067/S0717-75182006000200004.
Regulation of gene expression is controlled by many molecules which acting in concert may activate o repress a gene or a group of genes. The regulation requires of different nuclear receptors which as homodimers or heterodimers interact with DNA trough the so called DNA interaction domains. The DNA-receptor binding is determined by the presence of specific ligands. The final action of this complex is the activation or repression of gene expression. A number of molecules may act as ligands of nuclear receptors, being fatty acids and their derivatives one of the most important ligands of nutritional origin. Polyunsaturated fatty acids, acting as ligands of nuclear receptors may modulate a wide variety of molecular responses, such as adipocite differentiation, modifying insulin resistance, regulating vascular pressure, inducing apoptosis of tumor cells, modifying carbohydrate metabolism, etc. This new function of fatty acids as important modulators of gene expression goes beyond to the production of energy and essentiality. This work reviews the structure and function of nuclear receptors and the regulatory role of fatty acids in gene expression
Palabras clave : Nuclear receptors; regulation of gene expression; fatty acids as ligands; metabolism regulation.