Revista chilena de nutrición
versión On-line ISSN 0717-7518
VALENZUELA B, Alfonso y MORGADO T, Nora. BRIEF HISTORY OF THE RELATIONSHIP BETWEEN CHOLESTEROL AND CARDIOVASCULAR DISEASES. Rev. chil. nutr. [online]. 2006, vol.33, n.2, pp. 130-134. ISSN 0717-7518. doi: 10.4067/S0717-75182006000200001.
The association of plasma levels of cholesterol and atherogenesis was not an easy task. During the 18th century the first evidences about the discovery of cholesterol appeared. However, in the 19th century, from the work of Anichkov, was possible to establish that atheromas originate from cholesterol deposition. The discovery and the isolation of lipoproteins by John Goffman was another landmark in cholesterol history. The observation of Laurence Kinsell that diets rich in polyunsaturated fatty acids produce a reduction of plasma cholesterol was another important landmark. The discovery of the LDL-receptor by Goldstein and Brown was one of the most important discoveries about the relationship of cholesterol with cardiovascular diseases. This work reviews the main events of the history of cholesterol
Palabras clave : Cholesterol discovery; cholesterol and atherogenesis; lipoproteins and cholesterol.