Revista chilena de nutrición
versión On-line ISSN 0717-7518
ZAMORA S, Juan Diego; OTAROLA A, Isabel C y BRENES G, Oscar. APOPTOSIS AND ITS RELATIONSHIP WITH DIVERSE NUTRIENTS. Rev. chil. nutr. [online]. 2005, vol.32, n.3, pp.178-190. ISSN 0717-7518. http://dx.doi.org/10.4067/S0717-75182005000300002.
The homeostasis of the organism is maintained by a balance between cell division and death, apoptosis being one of the main mechanisms that regulate cell death. This process involves a quality control and a reparation pathway. A long list of diseases has been associated to a malfunctioning of this process, going from degenerative diseases such as Alzheimer´s, to proliferative ones, like cancer, including also autoimmune disorders, and others. It has been shown that different compounds, and nutrients from the diet, or derived from it, are closely related to apoptotic mechanisms, promoting, or inhibiting this type of cell death, affecting human health positively or negatively. These compounds have been associated to certain diseases. Among the most characterized of these nutrients are some amino acids and molecules with anti-oxidant activity such as zinc and the vitamins A and E, which are mainly antiapoptotic. On the other hand, isoflavones, omega 3 fatty acids, cholesterol, as well as butyric, arachidonic, and linoleic acids, are mainly proapoptotic. Some compounds like terpenoids have been associated with either anti or proapoptotic properties. All of these nutrients act at different levels of the apoptotic pathways, so the elucidation of their properties will help to develop complex therapies to prevent, treat or function as coadjuvants in the treatment of different diseases
Palabras clave : Apoptosis; biochemistry; nutrition; nutrients; diet.