Revista chilena de nutrición
versión On-line ISSN 0717-7518
FELIU, María S. y SLOBODIANIK, Nora H.. EFFECTS OF PROTEIN MALNUTRITION AND ITS NUTRITIONAL RECOVERY IN RATS´ THYMUS. Rev. chil. nutr. [online]. 2002, vol.29, n.2, pp.125-135. ISSN 0717-7518. http://dx.doi.org/10.4067/S0717-75182002000200007.
The thymus is severely affected by nutritional disorders. The activity of Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP) and 5nucleotidase (5NT) might affect T cell development. We study the effect of feeding growing rats with a protein-free diet and the posterior effect of a complete diet in the recovery of the thymus.. Changes in thymus weight, DNA content and the activity of ADA, PNP and 5NT were determined in thymocytes suspensions. The results indicate that the nutritional stress provoked by the administration of a protein-free diet from weaning onwards, affects the development of thymus expressed as loss of weight and DNA content, with an concomitant increase in the activity of ADA and PNP without 5NT changes. The increase would be an alternative mechanism to avoid the accumulation of high levels of deoxynucleotides, which would be toxic for T lymphocytes. The recovery diet was capable to reverse the effects provoked by the administration of experimental diets. This work reinforces our hypothesis related to diet as an important modifying factor that affects T lymphocyte development
Palabras clave : Thymus; protein malnutrition; nutritional recovery; thymic enzymes; DNA.