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Electronic Journal of Biotechnology
versión On-line ISSN 0717-3458
SONG, Le; CRUZ, Caroline; FARRAH, Samuel R y BANEY, Ronald H. Novel antiviral activity of dialdehyde starch. Electron. J. Biotechnol. [online]. 2009, vol.12, n.2, pp.13-14. ISSN 0717-3458. http://dx.doi.org/10.4067/S0717-34582009000200013.
A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS). Antiviral tests were carried out against three non-envelop viruses, including two bacterial viruses MS2 and PRD1, and one human virus Poliovirus. Dialdehyde starch aqueous suspensions were effective biocides against these three test viruses in a 1 hr exposure test. The antiviral activity was significantly enhanced in a four-hour exposure test, with maximum seven orders of magnitude reductions against MS2 and PRD1, and four-order reduction against Poliovirus. The antiviral activity of dialdehyde starch was found to be pH dependent, being more active in alkaline and acidic conditions than in neutral conditions.
Palabras clave : antiviral; biocide; dialdehyde starch; virus.