Abstract

OLIVARES, R.; SOTO-MOYANO, R.; HERNANDEZ, A.  and  ABOITIZ, F.. MILD PROTEIN PRENATAL MALNUTRITION SPECIFICALLY AFFECTS DEVELOPMENT OF THE ANTERIOR CORPUS CALLOSUM. Rev. chil. anat. [online]. 2002, vol.20, n.2, pp. 159-163. ISSN 0716-9868.  doi: 10.4067/S0716-98682002000200007.

Rats malnourished prenatally and during lactancy with a low-protein, isocaloric diet were shown to have smaller corpus callosums than controls at 45-65 days of age, which was consistent with differences in brain weight. Prenatally malnourished rats rehabilitated with a high-protein diet during lactancy showed normal brain weight and development of the mid-third and posterior third of the callosum, but reduced size of the anterior third. These findings suggest (i) that cortico-cortical (interhemispheric) connections are vulnerable to protein malnutrition; and (ii) the anterior callosum, connecting frontal areas across the midline is particulary affected by this type of malnutrition despite dietary rehabilitation during postnatal life

Keywords : Casein; Corpus callosum; Frontal cortex; Prenatal Malnutrition; Rat; Rehabilitation.