Revista chilena de infectología
versión ISSN 0716-1018
IZQUIERDO, Giannina et al. Neonatal herpes simplex encephalitis: clinical profile versus molecular biology. Rev. chil. infectol. [online]. 2012, vol.29, n.4, pp. 464-467. ISSN 0716-1018. doi: 10.4067/S0716-10182012000400019.
Herpes simplex encephalitis is a diagnostic challenge and causes high morbidity and mortality in children. Early suspicion of the disease and a rapid, safe and useful diagnostic test are relevant because up to 70% of the cases may die. We report the case of a newborn girl aged 25 days, who presented with a clinical picture that was compatible with herpes simplex encephalitis where the confirmation of the etiological diagnosis was delayed. Only by repeated real-time polymerase chain reaction it was possible to confirm the presence of herpes simplex virus type 1 in the cerebrospinal fluid.
Palabras clave : Herpes simplex encephalitis; newborn; diagnosis; polymerase chain reaction.