Revista chilena de infectología
versión impresa ISSN 0716-1018
AJENJO H, M. Cristina et al. Epidemiologial profile of invasive candidiasis in intensive care units at a university hospital. Rev. chil. infectol. [online]. 2011, vol.28, n.2, pp. 118-122. ISSN 0716-1018. http://dx.doi.org/10.4067/S0716-10182011000200003.
Invasive candidiasis (IC) epidemiology has changed in critically ill patients and limited data are available in Chile. Objective: To describe the epidemiological and microbiological profile of IC in critically ill patients. Methods: Observational prospective study conducted from October 2001 to August 2003 in critically ill adults with suspected or confirmed IC. Results: 53 patients met criteria for IC, finding 18 (33.9%) candidemias, 22 (41.5%) disseminated IC, and 13 (24.5%) local IC. We identified 8 (44.4%) C. albicans and 10 (55.6%) non-albicans Candida in candidemias. C. tropicalis was the predominant non-albicans species (27.7%). An 88.8 % of Candidas sp recovered in candidemias were fluconazole susceptible. Overall hospital mortality was 24.5%. Mortality in candidemia was significantly lower than in disseminated IC (16.6 vs 31.8%, p = 0.02). Conclusions: A higher proportion of non-albicans Candida was observed in candidemias from critically ill patients. However, most of these strains were fluconazole susceptible. A lower overall mortality was observed in candidemias.
Palabras llave : Invasive candidiasis; intensive care unit fluconazole.