SciELO - Scientific Electronic Library Online

 
vol.24 número1Micobacteriosis hepato-esplénica, forma inusual de probable tuberculosis extrapulmonar: Caso clínico y revisión bibliográficaPresentación inhabitual de un caso de neumonía bulosa aguda bilateral por Pneumocystis jiroveci complicada con neumotórax índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista chilena de infectología

versión impresa ISSN 0716-1018

Resumen

PIZARRO P, Rolando; AGUAD R, Lucia  y  CASTRO G, Juan L. Severe thrombocytopenia and human immunodeficiency virus infection: Report of two cases and review . Rev. chil. infectol. [online]. 2007, vol.24, n.1, pp. 63-67. ISSN 0716-1018.  http://dx.doi.org/10.4067/S0716-10182007000100011.

Thrombocytopenia is a relatively frequent complication in patients infected by human immunodeficiency virus (HIV). Most frequent mechanisms of thrombopenia are destruction of half-filled platelets by immunocomplex and defects in production. We present two cases of severe thrombocytopenia associated to HIV infection. Case 1: A male patient, 45 years old with fever and diarrhea that lasted for 1 month that presented with thrombopenia of 3.000 platelets/mm3. After beginning zidovudine and lamivudine therapy, he normalized the platelet count in 5 days. Case 2: A male patient of 30 years old, who suffered during one day migraine, nausea, vomits and then seizures. A criptococccal meningitis was confirmed. Concomitantly he had a platelet count of 59.000/mm3. He started antiretroviral therapy with zidovudina and lamivudina, then was changed to didanosine plus stavudine plus nevirapine. After 6 months of severe thrombocytopenia, platelets count was restored to normal values. A literature review is presented

Palabras llave : Thrombocytopenia; platelets; immune-complex.

        · resumen en Español     · texto en Español     · pdf en Español