Revista chilena de infectología
versión impresa ISSN 0716-1018
PIZARRO P, Rolando; AGUAD R, Lucia y CASTRO G, Juan L. Severe thrombocytopenia and human immunodeficiency virus infection: Report of two cases and review . Rev. chil. infectol. [online]. 2007, vol.24, n.1, pp. 63-67. ISSN 0716-1018. http://dx.doi.org/10.4067/S0716-10182007000100011.
Thrombocytopenia is a relatively frequent complication in patients infected by human immunodeficiency virus (HIV). Most frequent mechanisms of thrombopenia are destruction of half-filled platelets by immunocomplex and defects in production. We present two cases of severe thrombocytopenia associated to HIV infection. Case 1: A male patient, 45 years old with fever and diarrhea that lasted for 1 month that presented with thrombopenia of 3.000 platelets/mm3. After beginning zidovudine and lamivudine therapy, he normalized the platelet count in 5 days. Case 2: A male patient of 30 years old, who suffered during one day migraine, nausea, vomits and then seizures. A criptococccal meningitis was confirmed. Concomitantly he had a platelet count of 59.000/mm3. He started antiretroviral therapy with zidovudina and lamivudina, then was changed to didanosine plus stavudine plus nevirapine. After 6 months of severe thrombocytopenia, platelets count was restored to normal values. A literature review is presented
Palabras clave : Thrombocytopenia; platelets; immune-complex.