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Revista chilena de historia natural

versión impresa ISSN 0716-078X

Resumen

CRUZ-COKE, RICARDO. Sexagesimal scale for mapping human genome. Rev. chil. hist. nat. [online]. 2001, vol.74, n.1, pp. 91-97. ISSN 0716-078X.  http://dx.doi.org/10.4067/S0716-078X2001000000014.

In a previous work I designed a diagram of the human genome based on a circular ideogram of the haploid set of chromosomes, using a low resolution scale of Megabase units. The purpose of this work is to draft a new scale to measure the physical map of the human genome at the highest resolution level. The entire length of the haploid genome of males is deployed in a circumference, marked with a sexagesimal scale with 360 degrees and 1296000 arc seconds. The radio of this circunference displays a semilogaritmic metric scale from 1 m up to the nanometer level. The base pair level of DNA sequences, 10-9 of this circunsference, is measured in milliarsec unit (mas), equivalent to a thousand of arcsecond. The "mas" unit, correspond to 1.27 nanometers (nm) or 0.427 base pair (bp) and it is the framework for measure DNA sequences. Thus the three billion base pairs of the human genome may be identified by 1296000000 "mas" units in continous correlation from number 1 to number 1296000000. This sexagesimal scale covers all the levels of the nuclear genetic material, from nucleotides to chromosomes. The locations of every codon and every gene may be numbered in the physical map of chomosome regions according to this new scale, instead of the partial kilobase and Megabase scales used today. The advantage of the new scale is the unification of the set of chromosomes under a continous scale of measurement at the DNA level, facilitating the correlation with the phenotypes of man and other species

Palabras clave : human genome; DNA; chromosomes; genetic map.

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