Revista chilena de pediatría
Print version ISSN 0370-4106
AVARIA, María de los Ángeles et al. Transaminases increase: a manifestation of Duchenne's muscular dystrophy. Rev. chil. pediatr. [online]. 2012, vol.83, n.3, pp. 258-261. ISSN 0370-4106. http://dx.doi.org/10.4067/S0370-41062012000300007.
Commonly used in clinical practice, glutamic oxalacetic (GOT) and glutamic piruvic (GPT) transaminases are produced in various body tissues, including striated muscle, so their blood elevation is not due exclusively to liver disease. The objective of this study is to demonstrate the correlation between elevated creatinkinase (CK) and transaminases in patients with diagnosis of Duchenne muscular dystrophy (DMD), the most frequent neuromuscular disease in children. Patients and Method: Assessment in 61 children with diagnosis of DMD of CK, AST and ALT levels, and their correlation. Results: Aill patients had increase of CK ( = 13.363 IU/L), AST ( = 203 lU/L) and ALT ( = 194 IU/L) above normal values. The increase of transaminases related directly with the increase of CK. Conclusion: Patients with DMD have increased transaminases, so it is necessary to include this diagnostic possibility in a child with hypertransaminemia, prior to performing liver biopsy.
Keywords : Duchenne; muscular dystrophy; transaminases; creatinkinase.