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Revista chilena de pediatría

versión impresa ISSN 0370-4106

Resumen

CAVAGNARO S, FELIPE. Tumoral lysis syndrome in pediatrics. Rev. chil. pediatr. [online]. 2011, vol.82, n.4, pp.344-350. ISSN 0370-4106.  http://dx.doi.org/10.4067/S0370-41062011000400009.

Tumor lysis syndrome is a metabolic emergency resulting from the rapid and massive destruction of tumor cells, spontaneously or secondary to cytolytic therapy for cancer. This results in a huge imbalance of internal environment by releasing large amounts of intracellular contents into the interstitial and intravascular space, with serious clinical consequences or even death. The pediatric population is especially at risk of tumor lysis syndrome because it has a high rate of fast-growing tumors, such as those of hematologic origin. Proper recognition of the risk factors that can cause this syndrome, as well as specific prevention and treatment has substantially decreased complications and improved survival in these patients.

Palabras clave : Tumor lysis syndrome; quemotherapy; chronic renal disease; hyperuricemia.

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