Revista chilena de pediatría
versión impresa ISSN 0370-4106
SAAVEDRA S, IVÁN et al. Pediatric drugs pharmacokinetics. Rev. chil. pediatr. [online]. 2008, vol.79, n.3, pp. 249-258. ISSN 0370-4106. doi: 10.4067/S0370-41062008000300002.
Pharmacokinetics corresponds to the branch of pharmacology that studies the absorption, distribution, biotransformation and excretion of drugs in the body, in order to proportionate a reference line for interpretation of drug concentration in biological fluids, fundamental for clinical therapy. While adult pharmacology has increase greatly, advances in pediatric pharmacology have been poor. Therefore, drug prescription in children is essentially empirical on the basis of an inmature organism. An effective, secure and rational pediatric pharmacology requires exhaustive knowledgement of the developmental changes in relation to absorption, distribution, metabolism and excretion affecting pharmacokinetics parameters; therefore, the effective dose. This review describes fundamental differences between adult and pediatric pharmacokinetics. These differences must be considered when therapeutic strategies develop for newborns and children
Palabras clave : Pharmacokinetics; bioavailability; pediatric drugs.