Revista chilena de pediatría
versión impresa ISSN 0370-4106
ARENILLAS P., Silvana et al. Regulation of the immune response against infection caused by Helicobacter pylori. Rev. chil. pediatr. [online]. 2002, vol.73, n.2, pp. 108-115. ISSN 0370-4106. doi: 10.4067/S0370-41062002000200002.
The host response against H. pylori infection is ineffective in eliminating the bacteria. The innate immune system plays a central role in processing and displaying antigens from H. pylori. Regulatory cytokines (IL10 and IL12) might regulate a T-lymphocyte (Th) response type 1, leading to a chronic gastritis or a Th2 response with antibody production and bacterial erradication. IFN-g(Th1 response) might regulate the induction and expression of human leucocyte antigen-IIs (HLA-II) in epithelial cells, increasing H. pylori's adherence to the gastric epithelium and inducing apoptosis. IL-4 (Th2 response) might increase the expression of HLA-II, IgG, IgE viability and stimulation of T-cell growth. Finally recent studies are focussed on cellular apoptosis induction as a cellular growth control and as a defense response of the host to H. pylori infection
Palabras clave : Helicobacter pylori; lymphocytic response; H. pylori; infection; gastritis.