Boletín de la Sociedad Chilena de Química
versão impressa ISSN 0366-1644
TORRES, RENE et al. PROPIEDADES ANTIVIRALES DE COMPUESTOS NATURALES Y SEMI-SINTETICOS DE LA RESINA DE HELIOTROPIUM FILIFOLIUM. Bol. Soc. Chil. Quím. [online]. 2002, vol.47, n.3, pp. 259-263. ISSN 0366-1644. http://dx.doi.org/10.4067/S0366-16442002000300009.
A new compound called filifolinone 3 was synthesized from the unusual spiranic alcohol filifolinol 1, the principal compound isolated from the resinous exudate of Heliotropium filifolium. (fam.Boraginaceae) Both compounds and the ester derivative of 1, filifolinyl senecionate 2 were tested as antiviral agents against five virus species of importance in human diseases. The most active compound resulted 1, specially against polio virus, but with a tight relationship between antiviral dosis/cytotoxic dosis
Palavras-chave : Heliotropium filifolium; resinous exudate; filifolinol; filifolinone synthesis; antiviral properties.