Boletín de la Sociedad Chilena de Química
versão impressa ISSN 0366-1644
CHAUDHARY, ASHU; SWAROOP, RATAN e SINGH, R.. Tetraazamacrocyclic Complexes of Tin(II): Synthesis Spectroscopy and Biological screening. Bol. Soc. Chil. Quím. [online]. 2002, vol.47, n.3, pp.203-211. ISSN 0366-1644. http://dx.doi.org/10.4067/S0366-16442002000300002.
Sixteen to eighteen membered tetraamide macrocyclic ligands N4L1 and N4L2 have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with phthalic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4- dimethylaminopyridine. On reduction, these macrocyclic ligands give new tetraazamacrocycles N4L3 and N4L4 which form complexes with tin(II) chloride. The macrocyclic ligands and their complexes have been characterized by elemental analysis, molecular weight determinations, conductance, IR and 1H NMR spectral studies. The spectral data suggested hexacoordinated state for tin in these complexes. Conductivity data suggested that they behave as non-electrolytes. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles. The formulation of the complexes of the type [Sn(N4Ln)Cl2] has been established on the basis of chemical composition. The ligands and their complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential
Palavras-chave : Teraazamacrocycles; complexes; synthesis; Spectroscopy.