SciELO - Scientific Electronic Library Online

 
vol.44 número4DETERMINACION ESPECTROFOTOMETRICA DE COBRE EN FORMULACIONES MEDICAS, SALVADO DE TRIGO Y AGUAS POTABLESESTUDIO DE LOS PROCESOS DE TRANSFERENCIA DE ENERGIA ENTRE IONES Pr3+ DOPADOS EN Cs2NaYCl6 índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Boletín de la Sociedad Chilena de Química

versión impresa ISSN 0366-1644

Resumen

MENDOZA MARIN, SAURA; JARAMILLO MENA, VICTOR HUGO  y  VEGA HERRERA, MARIO. DETERMINACION DE METAMIZOL-SODICO EN SUPOSITORIOS POR CROMATOGRAFIA EN CAPA FINA DE ALTA EFICIENCIA (HPTLC). Bol. Soc. Chil. Quím. [online]. 1999, vol.44, n.4, pp. 479-485. ISSN 0366-1644.  http://dx.doi.org/10.4067/S0366-16441999000400012.

A quantitative method for metamizol-Na in suppositories made with Witepsol H-15 as fatty matrix, using High Performance Thin Layer Chromatography (HPTLC) is proposed and validated. Rosemont procedure based on statistical analysis of accuracy, precision, linearity and proportionality through the analytical assay of six replicates and three concentration levels representing 90, 100 and 110% of declared concentration was used. Accordingly validation procedure, the method is convenient and trustful because the Confident Limit of mean includes 100% of recovery, precise (CV = 2.45), linear (RV = 7.77 < F = 8.66), and proportional since Confident interval of intercept includes zero. The HPTLC method, proposed for quantitative analysis of metamizol-Na in suppositories do not differ statistically from the Official Method described in the German Pharmacopeia

Palabras clave : Metamizol-Na; High Performance Thin Layer Chromatography (HPTLC); densitometry; quantitative analysis; validation of analytical method.

        · resumen en Español     · texto en Español