Resumen

MARAMBIO, OSCAR; MONSALVE, ESTER  y  SCHMEDA-HIRSCHMANN, GUILLERMO. DNA BINDING ALKALOIDS FROM LOBELIA BRIDGESII HOOK ET ARN AND LOBELIA TUPA L. Bol. Soc. Chil. Quím. [online]. 1999, vol.44, n.3, pp. 385-389. ISSN 0366-1644.  doi: 10.4067/S0366-16441999000300016.

The methanolic extract of the aerial parts of Lobelia bridgesii and L. tupa (Lobeliaceae) showed activity in the DNA binding assay. Bioassay-guided isolation led to the alkaloids norlobelanidine and norlelobanidine as the main bioactive constituents of othe plant. At 0.50 mg/mL, the percentual DNA binding of both compounds were 79% and 71%, respectively

Palabras clave : Lobelia bridgesii; L. tupa; Lobelioideae; DNA binding; alkaloids; norlobelanidine; norlelobanidine.