Archivos de medicina veterinaria
versión impresa ISSN 0301-732X
BARONI, E. et al. Pharmacokinetics of propofol in 10 to 15 days old foals. Arch. med. vet. [online]. 2000, vol.32, n.2, pp. 193-200. ISSN 0301-732X. http://dx.doi.org/10.4067/S0301-732X2000000200006.
Pharmacokinetic variables of propofol were studied in 8 foals. Plasma levels of propofol at different time after a single intravenous dose of 2.4 mg/kg bw, were determined by HPLC. An open two compartments model was used to evaluate plasma levels of propofol and values of t1/2a, t1/2b, Vdc, Vdss, Vdb, Cltotal y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appropriate dose to be given
Palabras llave : pharmacokinetic; propofol; foals.